clathrin adaptors การใช้

• After binding IGF2 at the cell surface, IGF2Rs accumulate in forming clathrin-coated GGA family of clathrin adaptor proteins and accumulate in forming clathrin-coated vesicles.
• Second, arrestin links the receptor to elements of the internalization machinery, clathrin and clathrin adaptor AP2, which promotes receptor internalization via coated pits and subsequent transport to internal compartments, called endosomes.
• The proline-rich " N "-terminal region contains physiologically important binding sites for a ubiquitin ligase Itch and clathrin adaptor complex 3, but is likely disordered and dispensable for the kinase activity.